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Magical Nonsense

Dr. Joe Schwarcz: Cancer-cure ‘magicians’ prey on the desperate

 

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Alkaline Nonsense

DNAIt is so seductively simple.  If you want to avoid cancer, just make sure your body is “alkaline!”  Here is the rationale.  When a cell becomes cancerous it reduces its use of oxygen and cranks up its production of acids.  These conditions then allow such cells to multiply quickly.  To counter this, you have to ensure that cells get an adequate supply of oxygen and that the acids produced are neutralized.  How?  By introducing sources of oxygen such as hydrogen peroxide or ozone into the body and consuming “alkaline” foods.  If cancer has already taken a foothold, then it may be necessary to dose up on cesium, the “most alkaline nutritional mineral.”  So simple, and so wrong!

As so often happens, promoters of nonsensical therapies seize a few filaments of scientific fact and weave these into a tangled web that ensnares the desperate and the scientifically confused.  In this case, it all starts with the work of German physician Otto Warburg who received the 1931 Nobel Prize in medicine for his work on cellular metabolism.  Warburg showed that that the growth of malignant cells requires markedly smaller amounts of oxygen than that of normal cells and that their metabolism follows an “anaerobic” pathway leading to the production of lactic acid.  This notion lay dormant until the 1980’s when Dr. Keith Brewer, a physicist with no medical training, used it to support his perplexing theory of how potassium and calcium control the transport of glucose and oxygen into cells, and how irritation of the cell’s membrane interferes with this transport system.  The result, Brewer maintained, is the “Warburg effect,” which lowers the cell’s pH, reduces its oxygen supply, and causes changes in DNA characteristic of cancer.  He then went on to claim that cesium’s chemically similarity to potassium allows it to be readily taken up by cells, but that unlike potassium, it does not transport glucose into cells while allowing oxygen to enter.  As a result, cancer cells are enriched in oxygen, deprived of glucose, form less lactic acid, become more alkaline, and as a consequence, die.  Sounds good, but Brewer got the “Warburg effect” all wrong.  Cancer cells do shift to a mode of metabolism that doesn’t use oxygen, but this happens even in the presence of oxygen!

Brewer went on to buttress his argument by claiming that cancer is almost unknown among the Hopi Indians of Arizona, the highland Indians of Peru and the Hunza of North Pakistan.  Why?  Because due to the cesium in the soil, they have a “high pH” diet.  Whether these people actually do have a lower cancer rate is questionable, and even if this were the case, it could not be ascribed to cesium in the diet without further investigation.  But then to take the cake (undoubtedly cesium enriched) Brewer in 1984 published a paper with the following claim: “Tests have been carried out on over 30 humans and in each case the tumour masses disappeared.  Also, all pains and effects associated with cancer disappeared within 12 to 36 hours; the more chemotherapy and morphine the patient had taken, the longer the withdrawal period.”  Not only had he discovered the cancer cure that had eluded the thousands of PhDs and MDs working in cancer research around the world, but he also showed that chemotherapy was actually harmful.  Quite a claim!

And just where were these miraculously cured patients, and who had treated them?  Brewer refers to Dr. Hellfried Sartori (aka Prof. Abdul-Haqq Sartori) who had accomplished this incredible feat in the Washington D.C. area.  This is the same Dr. Sartori who in July of 2006 was arrested in Thailand for fraud and practicing medicine without a license.  He was charging desperate patients were up $50,000 for “cancer cures” which included cesium chloride injections.  The good doctor, who routinely promised that he could cure his patients of any disease, has a rather illustrious history.  Known as the notorious “Dr. Ozone” in the U.S. , he served five years in prison in Virginia and nine months in New York for defrauding patients with unapproved therapies such as cesium chloride injections, coffee enemas and ozone flushes.  Needless to say, there are no records of the patients whom, according to Brewer, Sartori cured of cancer.  Australian police are now looking into the deaths of six people who died after intravenous injections of cesium chloride at clinics following Sartori’s protocol.

Introducing ozone or hydrogen peroxide to raise cellular oxygen levels is a scientifically bankrupt idea, as is raising a cell’s pH with cesium chloride.  Of course, it is not the absurdity of the theory that rules out its effectiveness, it is the lack of evidence!  There are no controlled trials showing cancer being cured with ozone or cesium.  But there is evidence that cesium chloride can cause cardiac arrhythmia and death.  Granted, it is unlikely that this can happen from the oral doses being promoted by numerous alternative practitioners aimed at raising the body’s pH, but the idea that cesium chloride can neutralize acids in cells is sheer nonsense.

Yes, cesium is an “alkali” metal.  Dropping a piece of cesium metal into water does indeed produce an alkaline solution (and an explosion).  But cesium chloride is not the same as cesium metal, it is a neutral salt.  In any case, the blood’s pH cannot be altered by cesium chloride ingestion, or indeed with the ingestion of any food.  It is a marvelously buffered system, meaning that it resists any change in acidity.  It doesn’t matter what we eat or drink, our blood contains substances that can act as acids or bases to maintain our blood pH at 7.4.  The only body fluid that responds to diet in terms of pH is the urine.  Breads, cereals, eggs, fish, meat and poultry can make the urine more acidic while most, but not all, fruits and vegetables make the urine more alkaline.  A diet high in fruits and vegetables and low in meat can indeed reduce the risk of cancer, but this has absolutely nothing to do with changing the pH of cancer cells.  The idea of an “alkaline” diet to prevent or treat cancer may sound seductively simple, but in reality it is just simple minded.

Joe Schwarcz PhD

Forget Homeopathic Arsenic for Stress Reduction

stressDuring a recent talk on the relation between the body and the mind, I mentioned the newest anxiety-relieving craze, colouring books. Aimed at adults, these feature intricate patterns that provide quite a challenge for staying inside the lines. The contention is that focusing on the special patterns distracts the mind from anxiety and stress. Evidence is sketchy, but millions of colouring books are flying off the shelves, topping best-seller lists. That in itself says something about our society.

After my talk I was approached by a lady who claimed she had something better than colouring books to relieve anxiety and slipped a vial full of pills into my hand. She didn’t seem like a clandestine drug pusher so I thought I would look down and find some pills of lorezapam or maybe St. John’s Wort. Such was not the case. The label on the vial read “Arsenicum album 30C.”

No, she was not trying to poison me. These were homeopathic arsenic pills based on the curious notion that a substance that in large doses causes certain symptoms can, in homeopathic potency, repel the same symptoms. Since arsenic poisoning is associated with anxiety and restlessness, a person suffering such symptoms should find relief in a homeopathic dose of arsenic. In the bizarre world of homeopathy, potency increases with greater dilution, and a dose of 30C is said to be extremely potent. Such a pill is made by sequentially diluting a solution of arsenic a hundred fold thirty times and then impregnating a sugar pill with a drop of the final solution. At a dilution of 30C, not only is there no trace of arsenic left, there isn’t even a water molecule that has ever encountered any of the original arsenic.

Homeopathy is a scientifically bankrupt practice that was invented over two hundred years ago by German physician Samuel Hahnemann who was disenchanted with bloodletting and purging, common medical procedures at the time. He was a good man who searched for kinder and gentler treatments and homeopathy fit that rubric. Since knowledge of molecules was almost non-existent at the time, Hahnemann could not have realized that his diluted solutions contained nothing. Actually, the truth is that they did contain something. A hefty dose of placebo!

Now here is the kicker to this story. Hahnemann was quite accomplished in chemistry and actually developed the first chemical test for arsenic. In 1787 he found that arsenic in an unknown sample was converted to an insoluble yellow precipitate of arsenic trisulfide on treatment with hydrogen sulfide gas. When in 1832 John Bodle in England was accused of poisoning his grandfather by putting arsenic in his coffee, John Marsh, a chemist at the Royal Arsenal, was asked to test a sample of the coffee. While he was able to detect arsenic in the coffee using Hahnemann’s test, the experiment could not be reproduced to the satisfaction of the jury and Bodle was acquitted. Knowing that he could not be tried for the same crime again, he later admitted to killing his grandfather.

The confession infuriated Marsh and motivated him to develop a better test for arsenic. By 1836 he had discovered that treating a sample of body fluid or tissue with zinc and an acid converted any arsenic to arsine gas, AsH3, which could then be passed through a flame to yield metallic arsenic and water. The arsenic would then form a silvery-black deposit on a cold ceramic bowl held in the jet of the flame and the amount of arsenic in the original sample could be determined by comparing the intensity of the deposit with that produced with known amounts of arsenic.

The Marsh test received a great deal of publicity in 1840 when Marie LaFarge in France was accused of murdering her husband by putting arsenic into his food. Marie was known to have bought arsenic from a local chemist which she claimed was to kill rats that had infested the house. A maid swore that she has seen her mistress pour a white powder into her husband’s drink and Marie had also sent a cake to her husband who was travelling on business just prior to his becoming ill. The dead husband’s family suspected that Marie had poisoned him and somehow got hold of remnants of food to which she had supposedly added arsenic. The Marsh test revealed the presence of arsenic in the food and in a sample of egg nog, but when the victim’s body was exhumed the investigating chemist was unable to detect arsenic.

To help prove Marie’s innocence by corroborating the results of the investigation of the exhumed body, the defense enlisted Mathieu Orfila, a chemist acknowledged to be an authority on the Marsh test. Much to the defense’s chagrin, Orfila showed that the test had been carried out incorrectly and used the Marsh test to conclusively prove the presence of arsenic in LaFarge’s exhumed body. Marie was found guilty and sentenced to life in prison. The controversial case captured the imagination of the public and was closely followed through newspaper accounts making Marie LeFarge into a celebrity. It would also go down in the annals of history as the first case in which a conviction was secured based on direct forensic toxicological evidence. Because of Mathieu Orfila’s role in the case, he is often deemed to be the “founder of the science of toxicology.” The Marsh test became the subject of everyday conversations and even became a popular demonstration at fairgrounds and in public lectures. This had an interesting spin off. Poisonings by arsenic decreased significantly since the existence of a proven, reliable test served as a deterrent.

As far as claims about relieving anxiety with homeopathic arsenic go, well, they cause me anxiety. I think I’ll flush those homeopathic tablets down the drain (no worry about arsenic pollution here) and buy a colouring book.

Dr. Joe Schwarcz

Serious Nonsense

cancer wellness program“We’ve had more people reverse cancer than any institute in the history of health care, so when McGill fails, or Toronto hospitals fail, they come to us. It can be stage 4 cancer and we reverse it.” You can imagine why that quote caught my eye. Both McGill and University of Toronto have world-class cancer treatment centers, but unfortunately, when it comes to stage 4 cancers, which are the most deadly, the chance of successful treatment is low. So, who is it that claims success where the latest evidence-based treatments fail? “Dr.” Brian Clement, who runs the Hippocrates Health Institute in Florida, apparently has the answers that have evaded mainstream researchers. What sort of doctor is this fellow? One who has some sort of accreditation as a “nutritionist” from a diploma mill where they apparently teach some, let us say, “interesting” science. I’m judging by the following rather fascinating outpouring of nonsense-bedecked drivel from the Hippocrates Health Institute.

“Based on modern biophysics and ancient Chinese medicine, color frequencies are applied to acupuncture points using a light pen and crystal rods. This promotes hormonal balance, detoxification, lymph flow and immune support while reducing headaches and sleeplessness. Working on cellular memory where the cause of disease resides, color puncture promotes healing from within.” And all you have to do is shell out $120 for a 50 minute treatment. All this of course is laughable, but when it comes to claims about curing cancer, the humour quickly vanishes with the realization that it is real people with real cancer who are being duped. And going by the following asinine promo, that is just what is happening.

“One of the major treatment goals of The Cancer Wellness Program at Hippocrates Health Institute is to strengthen the basic vitality, flow, and coherency of a person’s BioEnergy Field upstream to affect and change their downstream physical mass. The changes in a person’s vibrational frequency or bioenergy field, once stabilized, changes the electrical/chemical milieu in their body so that it is more difficult for their cancer or tumor mass with its own specific vibrational frequency to be sustained.”.

This is inane claptrap is far from the only type of cancer treatment Hippocrates offers. Intravenous vitamins and wheat grass implants are standard fare. Implanted where? Well, let’s just say in areas where the sun doesn’t shine. Clement maintains that “every disease known to man, plus premature aging, can be successfully dealt with on a diet of organic plant based foods.” Apparently not mental disease, given that Clement surely follows this diet. Patients are also told to give up meat and dairy, and are asked to swallow some rather bizarre ideas. Genetics don’t matter much, Clement says, and what doctors say about the BRCA gene predisposing to breast cancer is false. On his regimen, this mental wizard claims, tens of thousands of people have reversed the final stages of cancer. I would love to see the evidence for that. This charlatan is in Canada right now, giving talks, mostly to entice First Nations people to visit his Institute in Florida for treatment. Just like that given to the unfortunate 11-year-old Ontario girl who suffered from leukemia. That had a very sad outcome. Let’s just say she was not one of the tens of thousands of patients that Clement claims to have successfully treated.

Joe Schwarcz PhD

Cancer Charlatans

photodynamic therapyWhat makes people defend the indefensible? A prime example of this conundrum is the case of Antonella Carpenter, a 71 year old “alternative practitioner” who was convicted of conducting a fraudulent scheme to cure cancer in Tulsa, Oklahoma and is likely looking at spending the rest of her life in prison. She is not a physician but has some training in physics and claims that she can cure cancer by injecting a tumour with a saline solution of food colouring and walnut hull extract followed by heating the area with a laser. She calls her treatment “Light Induced Enhanced Selective Hyperthermia,” for which she claims 100% efficacy without any side effects. Any claim of 100% efficacy is a hallmark of quackery since no drug of any kind works in such a foolproof fashion. Even worse, she sometimes told patients they had been cured. As is often the case, quacks unearth some legitimate process and then twist it out of proportion to hatch a money-making scheme.

In this case, the legitimate process is “photodynamic therapy.” The treatment of cancer involves some process by which cancer cells are destroyed while normal cells suffer less damage. Unfortunately, it isn’t possible to avoid collateral damage completely and cancer treatment via radiation or drugs is always burdened with side effects. In photodynamic therapy the idea is to introduce a chemical, known as a photosensitizer, that when activated by light interacts with oxygen to convert it into a very reactive form known as “singlet oxygen” that then attacks any organic compound it encounters with the result being cell death. The photosensitizer can be introduced intravenously followed by the tumour being exposed to long wavelength light via optical fiber. Alternately, the photosensitizer can be injected directly into a tumour and then the area exposed to light. In either case singlet oxygen is produced only within the tumour, minimizing damage to normal tissue. The process is applicable to certain types of tumours and is certainly not a cure-all for cancer.

It is this therapy that has been mentally mangled by Antonella Carpenter, who according to investigators cheated cancer patients out of their money and gave them false hope. In spite of any evidence of her treatment having any efficacy, supporters have sprung to her side, claiming that she was wrongly convicted by a kangaroo court. Here are some of the phrases they are pumping out: “The greedy and vindictive genocidal maggots who control the Cancer Industry and have the FDA and courts in their back pocket”…. “the medical mafia is hard at work twisting the truth and vilifying Dr. Antonella Carpenter and any other non-Allopathic practitioners and natural or alternative treatments as quackery”…. “Dr. Carpenter was vindictively targeted by the Medical Mafia and their Gestapo goons at the FDA for successfully curing dozens of cancer patients.” No. The truth is that she was targeted for subjecting cancer patients to a treatment that had no chance of working and was claiming she had cured them. That is evil.

Joe Schwarcz PhD

Microwaves and Blood

RBCThere is a lot of nonsense that goes around about microwaves. I’m sure you heard many of them. They destroy nutrients in food. They cause cancer if you stand next to a microwave oven. Microwaved water kills plants. All poppycock. And then there is the story about a woman who died because the blood she received in a transfusion had been warmed up in a microwave oven? The case of Norma Levitt is an interesting one and is often used by anti-microwave activists to prove that microwaves are dangerous. This case proves nothing of the sort. Here are the facts.

Norma Levitt had successful hip surgery at the Hillcrest Medical Center in Tulsa in 1989, but unfortunately died on the operating table after the procedure. She received blood during the operation which had been warmed in a kitchen microwave oven. After her death, the family launched a lawsuit claiming negligence because the blood had been warmed in a non-standard fashion. The defendants, the doctors involved in the operation, asserted that the patient had died of a blood clot, a complication of surgery. The court found for the defendants, whereupon they launched a successful lawsuit against the plaintiff’s attorneys for wrongful accusation. Each defendant was awarded $12,500.

Whenever blood is used for a transfusion it is warmed to body temperature. Heaters especially designed for this process are available in order to guard against overheating which can result in hemolysis, or destruction of the red blood cells. This in turn causes release of potassium from the cells and excess potassium can be lethal. The issue is one of overheating the blood, not of the method used. Microwave ovens heat very quickly and temperature control is difficult. That’s why they are not appropriate for warming blood. Nothing to do with microwaves being “dangerous!”

The allegations on the anti-microwave websites suggest that somehow exposure to microwaves produced some dangerous substance in the blood which killed Norma Levitt. This is nonsense. Overheating blood by any method produces the same result. No, blood should not be heated in a kitchen microwave before a transfusion, but this has absolutely no bearing on cooking with microwaves. This is a classic case of taking a smidgen of truth and twisting it out of proportion. And incidentally, the court did not find that the transfused blood was the cause of death.

Joe Schwarcz PhD

Food Babe Lesson #3

vani hariIn our continuing, but extremely challenging effort to educate the Food Babe on science, let us pick on a grapefruit.

“A chance finding of our study on ethanol-drug interactions was that citrus fruit juices may greatly augment the bioavailability of some drugs.” So began a paper published in 1991 in The Lancet, one of the most respected medical journals in the world. Dr. David Bailey and colleagues at the University of Western Ontario had been studying felodipine, a blood pressure–lowering drug, and wondered if it interacted with alcohol. They decided on a double-blind trial in which some subjects were to take the drug with alcohol and some without. This meant that the taste of alcohol had to be masked, and after some experimentation Dr. Bailey concluded that grapefruit juice was up to the task. To the researchers’ surprise, the alcohol had no effect, but in both groups the blood levels of felodipine were three times higher than expected. Bailey knew he was on to something.

It turned out that some compound specific to grapefruit inhibited the action of CYP3A4, an enzyme found in the wall of the intestine. This enzyme is part of the body’s detoxicating system and tackles intruders, such as medications. If its action is impaired, blood levels of these foreign substances can be expected to rise. Since CYP3A4 is known to be involved in the metabolism of numerous drugs, researchers suspected that felodipine would not be the sole medication to show a “grapefruit effect.” Indeed it was not. Various oral medications, ranging from heart-rhythm regulators and immunosuppressants to estrogen supplements and AIDS treatments, all interact with grapefruit juice. And the effect can last as long as 24 hours, meaning that drinking grapefruit juice at any time is contraindicated when taking drugs metabolized by CYP3A4. Since it isn’t completely clear which drugs fall into this category and which do not, and because of the known variation in CYP3A4 levels in different individuals, some experts suggest that grapefruit juice be avoided when taking any medication. Accordingly, many hospitals have taken grapefruit juice off the menu.

Grapefruit is not the only food to be involved in a drug-food interaction. Dairy foods can interfere with some antibiotics, broccoli can reduce the effect of anticoagulants, foods high in tyramine (aged cheese, red wine, soy sauce, sauerkraut, salami) can cause dramatic rises in blood pressure when coupled with antidepressants of the monoamine oxidase (MAO) inhibitor variety, and the absorption of digoxin (taken for congestive heart disease) is impaired by cereals such as oatmeal. And oh, all these interactions involve “natural” foods.

 

Dr. Joe Schwarcz

Murky Mercola

mercolaIf you haven’t heard of Joe Mercola, you have not been surfing the waves of health advice on the web. He is an osteopathic physician whose practice now is limited to offering mostly iffy medical advice on his website and selling a variety of questionable products. He claims his website “is not a tool to get me a bigger house and car, or to run for senate.”. He says he funds his site and therefore, is not handcuffed to any advertisers, silent partners or corporate parents and profit generated from the sale of the products he recommend goes right back into maintaining and building a better site, “ a site that, startling as it may be with all the greed-motivated hype out there in health care land, is truly for you.” Gee, that sounds like motherhood and apple pie. It seems though that not every penny earned goes back into the managing the website. Mercola lives high on the hog in a multi-million dollar estate in Chicago. That wouldn’t be objectionable if the edifice were built on gains from promoting sound science. But that is not the case.

Besides being critical of vaccination, calling microwave ovens dangerous, questioning whether the HIV virus is the cause of AIDS, opposing homogenized milk, claiming that sunscreens increase the risk of skin cancer, Mercola hypes and sells a variety of pseudoscience-laced products. Let’s start with “Dr. Mercola’s Earthing Universal Mat,” which is described thus: “When you walk barefoot on the Earth, there’s a transfer of free electrons from the Earth into your body that spread throughout your tissues. The effect is sufficient to maintain your body at the same negatively-charged electrical potential as the Earth. This simple process is called ‘grounding.’ If you constantly wear materials like rubber or ‘plastic’ shoes, which are both very effective insulators, you’ll be disconnected from the natural energy that flows from the Earth.” Well, in my view, the only thing you will be disconnected from is science. This business of improving health by walking barefoot or by using Mercola’s Earthing Mat is nonsense. But Mercola tells us that his mat “is a great way to complement any outside ‘barefooting’ you might be able to fit into your busy schedule. It’s a quick and easy way for you to get started grounding whether at home, at the office, or almost anywhere you go.” I prefer to get my grounding from science not fairy tales.

Dr. Mercola also sells books such as “Dark Deception” in which he describes how we need sun exposure for health. But he would prefer to expose you to the tanning beds he sells, the same ones health experts agree are dangerous and increase the risk of skin cancer. There is also Dr. Mercola’s “organic deodorant” with “baking soda as the “active ingredient.” Except that it isn’t very active. There are also supplements galore. Like “breast health formula,” “mushroom complex” and “silver solution,” none of is a solution to anything. His bamboo toilet paper I’m sure does as good a job as any other, but the claim that it is better because it is free of toxic BPA can be safely flushed away.

Dr. Joe Schwarcz

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